Medical Sensors Design Conference 2019

In this keynote session, Professor Luke Lee presents a smart SANDs (Speedy Analytical Nano-optofluidic Diagnostic system) that can help to predict and stop the spread of infectious disease. An example of a smart SANDs will be discussed, along with integrated molecular diagnostic systems (iMDx) that comprise three key elements: (1) a self-contained sample preparation and liquid biopsy on chip, which allows a rapid sample-to-answer readout platform; (2) ultrafast photonic PCR; and (3) smartphone optical system (SOS). This rapid precise molecular-level detection network by smart SANDs for human, agricultural, foods, and environmental health will radically improve global healthcare and empower us to create a new proactive, predictive, preventive medicine, and enhancing global biosecurity. Professor Lee also presents the development of organoids Microphysiological Analysis Platforms (MAP) that will predict the most effective treatment of diseases for each patient. Human induced pluripotent stem cells (iPSCs)-based organoids MAP provides an ideal model to address fundamental questions of molecular organogenesis and pathogenesis. In addition, patient-derived organoids can recapitulate patient responses and help personalized therapy. Current development of mini-brains MAP, pancreatic islets MAP, and kidney organoids MAP will be discussed. Together, these smart SANDs and organoids MAPs by the convergence of biology, chemistry, physics, and engineering will impact on quantitative life sciences and precision medicine.